Min Zhuo Selected Research

5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol

1/2022	Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice.
1/2021	Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis.
1/2021	Inhibition of calcium-stimulated adenylyl cyclase subtype 1 (AC1) for the treatment of neuropathic and inflammatory pain in adult female mice.
1/2020	Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain.
1/2020	Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice.
1/2019	Calcitonin gene-related peptide potentiated the excitatory transmission and network propagation in the anterior cingulate cortex of adult mice.
1/2016	Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model.
10/2014	Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice.
6/2014	Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain.
6/2012	Targeting neuronal adenylyl cyclase for the treatment of chronic pain.

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Min Zhuo Research Topics

Disease

58	Pain (Aches) 01/2022 - 02/2002
33	Chronic Pain 01/2022 - 08/2006
14	Neuralgia (Stump Neuralgia) 01/2022 - 01/2004
10	Fragile X Syndrome (Martin Bell Syndrome) 01/2020 - 04/2008
9	Peripheral Nerve Injuries 01/2018 - 07/2003
8	Hyperalgesia 01/2021 - 02/2002
6	Inflammation (Inflammations) 08/2014 - 10/2004
5	Mental Disorders (Mental Disorder) 01/2020 - 06/2007
5	Substance-Related Disorders (Drug Abuse) 09/2008 - 11/2002
4	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 01/2018
4	Hypersensitivity (Allergy) 11/2021 - 05/2015
4	Intellectual Disability (Idiocy) 01/2021 - 11/2009
4	Visceral Pain 01/2020 - 11/2015
4	Phantom Limb (Phantom Limbs) 12/2018 - 12/2012
4	Pruritus (Itching) 09/2013 - 09/2010
3	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022 - 10/2019
3	Type 2 Diabetes Mellitus (MODY) 01/2022 - 10/2019
3	Kidney Diseases (Kidney Disease) 01/2022 - 12/2021
3	Hyperkalemia 01/2022 - 10/2019
3	Chronic Renal Insufficiency 01/2022 - 01/2021
3	AIDS-Related Complex (ARC) 12/2018 - 01/2012
3	Memory Disorders (Memory Loss) 12/2017 - 01/2004
3	Mood Disorders (Mood Disorder) 01/2016 - 08/2010
3	Acute Pain 09/2008 - 11/2002
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2022 - 01/2021
2	Heart Failure 01/2022 - 01/2022
2	Parkinson Disease (Parkinson's Disease) 01/2021 - 05/2015
2	Chronic Disease (Chronic Diseases) 01/2021 - 10/2012
2	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2020 - 06/2014
2	Migraine Disorders (Migraine) 01/2020 - 01/2019
2	Acquired Immunodeficiency Syndrome (AIDS) 05/2019 - 10/2014
2	Wounds and Injuries (Trauma) 01/2018 - 01/2014
2	Neoplasms (Cancer) 01/2016 - 01/2012
2	Peritonitis 01/2012 - 01/2012
2	Body Weight (Weight, Body) 12/2006 - 11/2005
1	Urinary Tract Infections (Urinary Tract Infection) 01/2022
1	Myocardial Infarction 01/2022
1	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 01/2022
1	Stroke (Strokes) 01/2022
1	Atrophy 01/2022
1	Atrial Fibrillation 01/2022
1	Infections 01/2022

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2003
17	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 03/2019 - 02/2002
16	Analgesics (Analgesic Drugs)IBA 01/2022 - 06/2008
14	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2022 - 01/2004
11	5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanolIBA 01/2022 - 01/2011
11	PlasticsIBA 01/2020 - 08/2006
10	CalciumIBA 01/2022 - 01/2004
9	Pharmaceutical PreparationsIBA 10/2021 - 06/2007
9	Glutamic Acid (Glutamate)FDA Link 01/2020 - 02/2002
9	Fragile X Mental Retardation ProteinIBA 01/2020 - 04/2008
7	AMPA Receptors (AMPA Receptor)IBA 01/2016 - 09/2005
6	N-Methylaspartate (NMDA)IBA 01/2020 - 02/2002
6	Freund's AdjuvantIBA 08/2014 - 11/2002
5	Calmodulin (Calcium-Dependent Activator Protein)IBA 08/2006 - 01/2004
4	Formaldehyde (Formol)FDA Link 01/2022 - 11/2002
4	Sodium-Glucose Transport ProteinsIBA 01/2022 - 10/2019
4	Cyclic AMP (AMP, Cyclic)IBA 01/2021 - 11/2002
4	ZymosanIBA 01/2020 - 06/2014
4	Protein Kinase CIBA 01/2018 - 12/2010
4	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2016 - 04/2008
3	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2022 - 11/2020
3	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2021 - 10/2009
3	EnzymesIBA 01/2020 - 10/2009
3	adenylyl cyclase 1IBA 01/2020 - 06/2014
3	Glutamate Receptors (Glutamate Receptor)IBA 01/2017 - 02/2002
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2016 - 07/2008
3	Transcription Factors (Transcription Factor)IBA 01/2012 - 04/2006
3	Peptides (Polypeptides)IBA 09/2011 - 12/2006
3	Calcium-Calmodulin-Dependent Protein Kinase Type 4IBA 10/2008 - 01/2004
2	SodiumIBA 01/2022 - 10/2021
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 10/2021
2	Glucagon-Like Peptide-1 ReceptorIBA 01/2022 - 11/2020
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/2021 - 05/2015
2	Protein Isoforms (Isoforms)IBA 01/2021 - 02/2006
2	Opioid Analgesics (Opioids)IBA 01/2021 - 01/2020
2	Calcitonin Gene-Related PeptideIBA 01/2020 - 01/2019
2	NeuropeptidesIBA 01/2019 - 11/2005
2	Ion Channels (Ion Channel)IBA 01/2018 - 01/2016
2	Hemoglobins (Hemoglobin)IBA 01/2018 - 01/2012
2	Kainic Acid Receptors (Kainate Receptor)IBA 01/2016 - 01/2007
2	Gabapentin (Neurontin)FDA LinkGeneric 10/2014 - 06/2014
2	ColforsinIBA 08/2014 - 11/2002
2	Calcium-Calmodulin-Dependent Protein KinasesIBA 01/2014 - 06/2002
2	Kainic Acid (Kainate)IBA 09/2013 - 06/2011
2	Histamine (Histamine Dihydrochloride)FDA Link 09/2013 - 12/2011
2	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 10/2008 - 04/2006
2	Morphine (MS Contin)FDA LinkGeneric 06/2008 - 11/2005
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	patiromerIBA 01/2022
1	omega-Chloroacetophenone (Mace)IBA 01/2022
1	Blood Proteins (Serum Proteins)IBA 01/2022
1	apixabanIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022

Therapy/Procedure

5	Surgical Amputation (Amputations) 01/2022 - 12/2012
3	Analgesia 01/2021 - 01/2016
2	Renal Dialysis (Hemodialysis) 01/2022 - 01/2021
2	Ligation 01/2018 - 11/2005
2	Therapeutics 01/2016 - 03/2012